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Microbiology and Molecular Genetics Michigan State University

2215 Biomedical Physical Sciences East Lansing, MI 48824-4320

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517-884-5287

Chair: 517-884-5292

Fax: 517-353-8957

Schwartz Richard C.

Richard C. Schwartz, Ph.D.

Professor

Ph.D., 1980, Massachusetts Institute of Technology
Postdoctoral Fellow, 1980-1983, University of California, San Diego
Postdoctoral Fellow,
1983, California Institute of Technology
Postdoctoral Fellow,
1983-1986, University of California, Los Angeles

Address:
Department of Microbiology and Molecular Genetics
4177 Biomedical Physical Sciences
Michigan State University
East Lansing, MI 48824

Microbiology Site
MSU
East Lansing , Michigan , 48823 United States

Research

My primary research interests focus on the impact of a high fat diet on mammary tumorigenesis, the role of inflammatory and immune processes in mammary tumorigenesis, and the roles of estrogen and progesterone in regulating the expression of proinflammatory genes in mammary epithelial cells and inflammatory processes in the mammary gland. We are also examining the role of C/EBP beta in regulating the expression of the progesterone receptor in mammary gland development. Recent work, in collaboration with Dr. Sandra Haslam (Dept. of Physiology) has shown a pubertal window to the promotional effects of a high fat diet in DMBA-induced mammary mutagenesis in a BALB/c mouse model system. The promotional effects of a high fat diet are likely caused by enhanced expression of growth factors, enhanced angiogenesis, and altered immune function.  We have also recently shown a role for estrogen and progesterone in the recruitment of macrophages and eosinophils to the developing mammary gland, where these leukocytes have essential roles in mammary gland development. 

Publications by Richard C. Schwartz, Ph.D.

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